"目錄號: HY-14375
Metabolic Enzyme/Protease -
CB 300919是CB30865的水溶性類似物，對人CH1卵巢癌外植體的IC50為2 nM。
Nampt
相關產品
FK866 -GNE-617 hydrochloride -GMX1778 -STF-118804 -Nampt-IN-1 -P7C3 -CB30865 -
生物活性
Description
CB 300919 is a water-soluble analogue of CB30865; has a continuous exposure (96 h) growth inhibition IC50 value of 2 nM in human CH1 ovarian tumor xenograft.IC50 value:Target: Nampt
References
[1].Lockman JW, et al. Analogues of 4-[(7-Bromo-2-methyl-4-oxo-3H-quinazolin-6-yl)methylprop-2-ynylamino]-N-(3-pyridylmethyl)benzamide (CB-30865) as Potent Inhibitors of Nicotinamide Phosphoribosyltransferase (Nampt).? J. Med. Chem., 2010, 53 (24), pp 8734-87
[2].Bavetsias, V. et al. The Design and Synthesis of Water-Soluble Analogues of CB30865, a Quinazolin-4-one-Based Antitumor Agent.? Journal of Medicinal Chemistry? (2002),? 45(17), 3692-3702.
最后編輯于 ：2017.12.11 15:43:03
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