"目錄號: HY-14859

GPCR/G Protein-

Dipraglurant (ADX 48621)是mGluR5拮抗劑，IC50為21 nM。

mGluR

相關產品

CTEP-LY341495-LY354740-LY404039-RG7090-Mavoglurant-MPEP Hydrochloride-Topiramate-JNJ-40411813-L-Glutamine-FITM-JNJ16259685-MTEP hydrochloride-(S)-MCPG-ADX-47273-

生物活性

Description

Dipraglurant (ADX 48621) is a mGluR5 antagonists with IC50 of 0.021 μM. IC50 Value: 0.021 μM [1]Target: mGluRDipraglurant (ADX-48621) from Addex Therapeutics showed in vivo activity in different anxiety models in rat50 and is currently in phase II for the treatment of dyskinesia in Parkinson's disease.

Clinical Trial

NCT01336088

Addex Pharma S.A.

Parkinson's Disease

April 2011

Phase 2

NCT02447640

Johns Hopkins University-Addex Pharma S.A.

Healthy

April 2015

Phase 1

NCT01336088

Addex Pharma S.A.

Parkinson's Disease

April 2011

Phase 2

NCT02447640

Johns Hopkins University-Addex Pharma S.A.

Healthy

April 2015

Phase 1

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References

[1].The Synthesis and Use of Certain Pyridine Derivatives? as Modulators of the G-protein Coupled Receptors? mGlu5 and P2Y12