"目錄號: HY-14403

MAPK/ERK PathwayStem Cell/Wnt-

ERK5-IN-1有效抑制ERK5, EC50為0.19 μM, IC50為0.087 μM,? 抑制LRRK2[G2019S] 時, IC50為0.026μM。

ERK

相關產品

SCH772984-GDC-0994-XMD8-92-TIC10-VX-11e-FR 180204-Tauroursodeoxycholate Sodium-Tomatidine-VRT752271-APS-2-79-Corynoxeine-Astragaloside IV-DEL-22379-XMD17-109-Mogrol-

生物活性

Description

ERK5-IN-1 exhibits potent inhibition of ERK5 with cellular EC50 values of 0.19 μM and enzymatic IC50 values of 0.087 μM and of LRRK2[G2019S] with enzymatic IC50 values of 0.026μM.

References

[1].Deng X, et al. Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones. Eur J Med Chem. 2013;70:758-767.